A SIMPLE KEY FOR FRACTAL STORM (SELF-LAID UNVEILED

In the LSD-bound crystal framework, the side chain of the lid residue L209EL2 kinds in depth hydrophobic contacts with both equally LSD and surrounding residues in TMs III, IV, and V (Figure 4C). When the lid moved apart to reveal the binding pocket in simulation, various of these contacts broke. We So hypothesized that L209EL2 acts to be a latch,